To properly coordinate cell behaviour, signalling mechanisms have developed to enable cells to communicate with one another. A failure of cell signalling leads to pathological conditions and different diseases may develop. Maintaining tissue homeostasis depends on the extracellular signals that control the basic functions of cells. The main molecular instruments of extracellular communication are receptor tyrosine kinases (RTK). Their importance is emphasized more against the evidence regarding their pathological functions – over 80 human pathologies are associated with the mutation of RTK genes, such as cancer, developmental disorders and metabolic syndrome.

The research team is focused on several less-explored features of RTK, particularly with regard to the regulation of bone growth. The team is also researching the development and testing of new drugs to suppress the pathological features of RTK.

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