Genome Integrity Research Group
All research in the field of genetics began in Brno in 1865, when Johann Gregor Mendel described the fundamental laws of heredity in organisms. The genetic information of a cell is written in DNA molecules and is collectively known as the cellular genome. Under the influence of the physical and chemical effects of the external environment and its own cellular metabolism, DNA is constantly being damaged. Information encoded in the genome is therefore distorted and errors occur, which, if not corrected, result in a failure of the functions of cells, tissues and eventually, the whole organism.
The main objective of the research team is to decipher the internal functions of homologous recombination, which is a key process applied to repair breaks in double-strand DNA, which is the most dangerous form of its damage. Homologous recombination is also responsible for genetic variability during reduction cell division. Changes to the implementation and regulation of recombination are associated with human infertility, miscarriages and genetic diseases, particularly cancer. In the future, advances in gene research might help to eradicate diseases such as haemophilia or cystic fibrosis, and significantly improve the treatment of cancer.