Disease models based on stem cells are used to better understand the development of diseases and to test potential therapeutic approaches. The research team is exploring human pluripotent stem cells, their cultivation and differentiation.

The main research interest of the team is aimed towards the use of these cells to model human diseases that result in cardiomyopathy and heart failure. With the use of reprogrammed human cells and human embryonic stem cells with modified genomes, the team is creating models of monogenetic diseases involving cardiomyopathy. Modelling based on stem cells is complemented by an analysis of both animal models and human samples.

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