Every twenty minutes, one person in the Czech Republic dies from cancer. Each year, 27,000 people succumb to it. Around the world, around 15 million people are diagnosed with cancer every year, 300,000 of whom are children, and around 80,000 lose the fight against the disease. Over 60% of the children cured of cancer suffer consequences during adulthood, such has infertility, heart failure or other forms of cancer. The causes of cancer in children are largely unknown. This is due to the fact that the number young oncologic patients is relatively low; 350–400 children get cancer out of the 95,000 new patients in the Czech Republic. Moreover, each child’s tumour is specific in terms of its origin, progression and prognosis.

A personal approach is emphasized during treatment, which is why the research team is focusing on personalized treatment procedures in paediatric oncology. The objective is to use the current theranostic approaches to improve the treatment results and reduce the long-term morbidity and late effects of oncologic diseases and the associated necessary treatment. The team is also focusing on incorporating new anticancer drugs into the earlier stages of treatment and on establishing a functional regional model for long-term monitoring, with a transition from paediatric treatment into complex adulthood treatment as a platform for studying long-term toxicity after the treatment of cancer in childhood, risk factors and methods of reducing the impacts of the treatment on the body.

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