Discovering hearts through imaging

doc. MUDr. Roman Panovský, Ph.D.

  • Project of mapping patients with Duchenne muscular dystrophy
  • MINOCA – a unique benefit of CMR in patients with MINOCA syndrome

Research focus
The Cardiovascular Magnetic Resonance research team (CMR) is focused on the development of new protocols of heart imaging and identifying novel imaging biomarkers for the prediction of early myocardial dysfunction. The main purpose is to improve the non-invasive diagnostics of early forms of myocardial diseases, contributing especially to heart failure. Early and accurate diagnosis of myocardial dysfuncti­on and structural abnormalities that are known to precede the development of manifest symptomatic heart failure can provide several potential benefits and can also lead to better short-term and long-term prognosis of patients, the decrease of patient morbidity and mortality, improving their quality of life and potentially saving public resources.

Research objectives

  • To test for a novel CMR protocol to improve early detection of myocardial injury in Duchenne and Becker muscular dystrophy patients.
  • To prove that CMR can detect higher prevalence and earlier stages of cardiac involvement in patients with sarcoidosis, in comparison with the commonly used methods.
  • To find novel CMR and laboratory markers for the diagnosis of cardiotoxicity in oncological groups of patients after cardio toxic chemotherapy.

Top publications

  • PANOVSKÝ, R., PEŠL, M., MÁCHAL, J., HOLEČEK, T., FEITOVÁ, V., JUŘÍKOVÁ, L., MASÁROVÁ, L., PEŠLOVÁ, E., OPATŘIL, L., MOJICA-PISCIOTTI, ML., KINCL, V., Quantitative assessment of left ventricular longitudinal function and myocardial deformation in Duchenne muscular dystrophy patients. Orphanet Journal of Rare Diseases. 2021 Jan 30;16(1):57. doi: 10.1186/s13023-021-01704-9.
  • PANOVSKÝ, R., DOUBKOVÁ, M., HOLEČEK, T., MÁCHAL, J., FEITOVÁ, V., MADÁROVÁ, L., OPATŘIL, L., MOJICA-PISCIOTTI, ML., KINCL, V., Myocardial T1mapping using SMART1 Map and MOLLI mapping in asymptomatic patients with recent extracardiac sarcoidosis. NMR in Biomedicine. 2020 Nov;33(11):e4388. doi: 10.1002/nbm.4388.
  • HAUSVATER, A., SMILOWITZ, NR., LI, B., REDEL-TRAUB, G., QUIEN, M., QIAN, Y., ZHONG, J., NICHOLSON, JM., CAMASTRA, G., BIERE, L., PANOVSKÝ, R., SÁ, M., GERBAUD, E. SELVANAYAGAM, JB., AL-MALLAH, MH., EMRICH, T., REYNOLDS, HR. Myocarditis in Relation to Angiographic Findings in Patients With Provisional Diagnoses of MINOCA. JACC Cardiovascular Imaging. 2020 Sep;13(9):1906-1913. doi:10.1016/j.jcmg.2020.02.037.
  • MASÁROVÁ, L., MOJICA-PISCIOTTI, ML., PANOVSKÝ, R., KINCL, V., PEŠL, M., OPATŘIL, L., MÁCHAL, J., NOVÁK, J., HOLEČEK, T., JUŘÍKOVÁ, L., FEITOVÁ, V., Decreased Global Strains of LV in Asymptomatic Female Duchenne Muscular Dystrophy Gene Carriers Using CMR-FT. JACC Cardiovascular Imaging. 2020 Nov 12:S1936-87820)30889-5. doi: 10.1016/j.jcmg.2020.09.016.
  • PANOVSKÝ, R., PLEVA, M., FEITOVÁ, V., et al. Left atrium assessment: the evolving role of MRI. Journal of Cardiovascular Medicine. 2015, 16(10), 671-80.
  • PANOVSKÝ, R., BOROVA, J., PLEVA, M., et al. The unique value of cardiovascular magnetic resonance in patients with suspected acute coronary syndrome and culprit-free coronary angiograms. BMC Cardiovascular disorders. 2017, 17(1), 170.
  • PANOVSKÝ, R., PEŠL, M., HOLEČEK, T., et al. Cardiac profile of the Czech population of Duchenne muscular dystrophy patients: a cardiovascular magnetic resonance study with T1 mapping. Orphanet J Rare Dis 2019: 14:10.

Other selected results

  • Cardiovascular magnetic resonance provided a powerful incremental diagnostic value in the cohort of patients with suspected acute coronary syndrome and unobstructed coronary arteries. The CMR is highly recommended to be incorporated as an inalienable part of the diagnostic algorithms in these patients.