Research focus The NCI-CMR research group is focused on development of new protocols of heart imaging and identifying novel imaging biomarkers for the prediction of early myocardial dysfunction. The main purpose is to improve the noninvasive diagnostics of early forms of myocardial diseases contributing especially to heart failure. Early and accurate diagnosis of myocardial dysfunction and structural abnormalities that are known to precede the development of manifest symptomatic heart failure can provide several potential benefits and can lead to better short-term and long-term prognosis of patients, decrease patient morbidity and mortality, improve their quality of life and potentially save public sources.
To test a novel CMR protocol to improve early detection of myocardial injury in Duchenne and Becker muscular dystrophy patients.
To prove that CMR can detect higher prevalence and earlier stages of cardiac involvement in patients with sarcoidosis in comparison with commonly used methods.
To find novel CMR and laboratory markers for the diagnosis of cardiotoxicity in oncological group of patients after cardiotoxic chemotherapy.
MELUZÍN, J., JANOUŠEK, J., MAYER, J., GROCH, L., HORNACEK, I., HLINOMAZ, O., KALA, P., PANOVSKÝ, R., et al. Three-, 6-, and 12-month results of autologous transplantation of mononuclear bone marrow cells in patients with acute myocardial infarction. International Journal of Cardiology. 2008; 128(2):185-192.
PANOVSKÝ, R., PLEVA, M., FEITOVÁ, V., et al. The Prognostic Impact of Myocardial Late Gadolinium Enhancement. Cardiology in Review. 2014, 22(3), 128-139.
PANOVSKÝ, R., PLEVA, M., FEITOVÁ, V., et al. Left atrium assessment: the evolving role of MRI. Journal of Cardiovascular Medicine. 2015, 16(10), 671-80.
PANOVSKÝ, R., BOROVA, J., PLEVA, M., et al. The unique value of cardiovascular magnetic resonance in patients with suspected acute coronary syndrome and culprit-free coronary angiograms. BMC Cardiovascular disorders. 2017, 17(1), 170.
PANOVSKÝ, R., PEŠL, M., HOLEČEK, T., et al. Cardiac profile of the Czech population of Duchenne muscular dystrophy patients: a cardiovascular magnetic resonance study with T1 mapping. Orphanet J Rare Dis 2019: 14:10.
PANOVSKÝ, R., DOUBKOVÁ, M., HOLEČEK, T., et al. Myocardial T1 mapping using SMART1Map and MOLLI mapping in asymptomatic patients with recent extracardiac sarcoidosis. NMR in Biomedicine. 2020;e4388. https://doi.org/10.1002/nbm.4388
Other selected results
Cardiovascular magnetic resonance provided a powerful incremental diagnostic value in the cohort of patients with suspected acute coronary syndrome and unobstructed coronary arteries. The CMR is highly recommended to be incorporated as an inalienable part of the diagnostic algorithms in these patients.
INTERNATIONAL CLINICAL RESEARCH CENTER
OF ST. ANNE’S UNIVERSITY HOSPITAL BRNO