SLEEP MEDICINE

Breathe Easily, Sleep Well

prof. MUDr. Ondřej Ludka, Ph.D.

  • Publication: Ludka O, Štěpánová R, Vyskočilová M, Galková L, Mikolášková M, Bělehrad M, Košťálová J, Mihalová Z, Drozdová A, Hlasenský J, Gacik M, Pudilová L, Mikušová T, Fischerová B, Sert-Kuniyoshi F, Somers VK, Špinar J, Kára T. Sleep apnea prevalence in acute myocardial infarction – The Sleep Apnea in Post-acute Myocardial Infarction Patients (SAPAMI) Study. International journal of cardiology 2014;176:13-19
  • Organization of Congresses: In 2017, the World Sleep Congress was held in Prague, which was organized by the World Sleep Society and the chair of the Local Organizing Committee was prof. Ludka. Prof. Ludka was also co-chair of Congress Technologist Committee.
  • Contract research: Honeywell, Aerospace Divison – development of a new technology for monitoring and evaluating the state of alertness of the pilot with use in aviation.

Research focus
The Sleep Medicine Research team plans to initiate three crucial research studies on assessing the role of sleep apnea treatment, prognosis of patients after myocardial infarction and prevention of sudden cardiac death and atrial fibrillation recurrence. An important part of the SMED team activities will be continuous data analysis from projects where enrollment of patients has already been completed. This way we can evaluate a rising opportunity to identify severe risk factors and to eliminate it via a corresponding therapy. The SMED Research team would like to establish one of the first centers capable of monitoring the frequency and appropriate use of technologies for SA treatment. The center of telemonitoring will be established as an integral part of the current Cardiovascular Sleep Research Center and its support will be crucially important to improve the reliability of outcomes of the above described sleep research studies.

Research objectives

  • To characterize the role of sleep apnea and its treatment in myocardial infarction, heart failure, sudden cardiac death and atrial fibrillation.
  • Elucidate pathophysiological mechanisms underlying sleep apnea.
  • Evaluate the relationship between sleep apnea and metabolic disorders.

Main partners

  • The Charité – Universitätsmedizin Berlin, Berlin, Germany
  • The University of Milan, Milan, Italy
  • Mayo Clinic, Rochester, MN, USA

Offered services and expertise

  • Fully functional Sleep lab certified by Czech Sleep Research and Sleep Medicine Society and also certi­fied as a research center by European Sleep Research Society.
  • Polygraphy and manual or automatic titration of positive airway pressure therapy (CPAP, BiPAP, ASV, AVAPS etc.).
  • Full polysomnography.

Top publications

  • KONEČNÝ, T., GESKE, J., LUDKA, O., ORBAN, M., BRADY, P., ABUDIAB, M., ALBUQUERQUE, F., PLACEK, A., KÁRA, T., SAHAKYAN, K., GERSH, B., TAJIK, A., ALLISON, T., OMMEN, S., SOMERS, V. Decreased Exercise Capacity and Sleep Disordered Breathing in Patients with Hypertrophic Cardiomyopathy. Chest. 2015, 147(6), 1574-1581.
  • LUDKA, O., ŠTĚPÁNOVÁ, R., VYSKOČILOVÁ, M., GALKOVÁ, L., MIKOLÁŠKOVÁ, M., BĚLEHRAD, M., KOŠŤÁLOVÁ, J., MIHALOVÁ, Z., DROZDOVÁ, A., HLÁSENSKÝ, J., GACIK, M., PUDILOVÁ, l., MIKUŠOVÁ, T., FISCHEROVÁ, B., SERT-KUNIYOSHI, F., SOMERS, V., ŠPINAR, J., KÁRA, T. Sleep apnea prevalence in acute myocardial infarction – The Sleep Apnea in Post-acute Myocardial Infarction Patients (SAPAMI) Study. International Journal of Cardiology. 2014, 176(1), 13-19.
  • KONEČNÝ, T., SOMERS, V. Sleep-Disordered Breathing in Hypertrophic Cardiomyopathy: Challenges and Opportunities. Chest. 2014, 146(1), 228-34.
  • ČUNDRLE, I., SOMERS, V., JOHNSON, B., SCOTT, C., OLSON, L. Exercise End-Tidal Carbon Dioxide Predicts Central Sleep Apnea in Heart Failure Patients. Chest. 2015, 147(6), 1566-1573.
  • ČUNDRLE, I., SOMERS, V., SINGH, P., JOHNSON, B., SCOTT, C., VAN DER WALT, C., OLSON, L. Leptin Deficiency Promotes Central Sleep Apnea in Patients With Heart Failure. Chest. 2014, 145(1), 72-78.

Other selected results

This research group detected a high prevalence of previously undiagnosed SA in acute myocardial infarction patients. In this population, peak occurrence of MI onset was between 6 AM and noon in SA patients, similar to what is observed in the general population. Considering that this is a group at high risk for heart failure, fatal arrhythmia, recurrent MI and sudden death, treatment of SA may provide an important strategy for secondary prevention. Whether treating SA reduces post-MI morbidity and mortality awaits the findings of randomized controlled trials.