13. 11. 2019 |

Alzheimer's Endowment Fund, three enthusiastic young ladies and a team of authors have created a unique book that describes Alzheimer's disease literally from A to Z. We are proud that Mgr. Hana Marková, Ph.D. et Mgr. Kateřina Čechová and Mgr. Adéla Fendrych Mazancová are members of a joint project of the The International Clinical Research Center of St. Anne's University Hospital Brno (FNUSA-ICRC) and the Cognitive Center of the Department of Neurology in Motol University Hospital called Czech Brain Aging Study (CBAS).
Head of the Cognitive Disorders and Dementia Research Team FNUSA-ICRC, prof. Assoc. MUDr. Jakub Hort, Ph.D., contributed the introductory word and MUDr. Kateřina Sheardová, head of the FNUSA-ICRC Memory Disorders Research Center, wrote a chapter on the latest findings in the field of disease prevention and non-pharmacological interventions. Other members of the CBAS project, such as MUDr. Ondrej Lerch, MUDr. Jiří Cerman and MUDr. Rastislav Šumec participated ond book too.
“We were inspired to write the book by our daily work with Alzheimer's patients and their loved ones who try to understand the origin of the disease as much as possible. The most common questions we hear in the outpatient clinic also relate to how to fight the disease itself, and how to prevent it. Active approach to treatment is perceived very positively by both patients and family. Plenty of information about the course of the disease helps carers to respond best to the patient's needs and to maintain their mental health in this difficult situation. In addition to answering all these questions, this book also provides practical advice that can help in day-to-day care of a patient with dementia, ”summarized Kateřina Sheardová.
The book aims to guide readers in the maze of questions related to Alzheimer's disease. Its style and language is available to everyone. It is also useful for those who have not yet encountered this disease. The book can also be an inspiration for professionals or students interested in this issue. There is no need to read it from beginning to end, everyone can find exactly what he is interested in and need to return to the omitted chapters later.

Publication „In a maze called Alzheimer“, it can be bought in all good bookstores, and is also available as an e-book.

Photo: Michaela Eiseltova


30.10.2019 |

On the occasion of the World Day of Stroke, the Educational Day attracted to the St. Anne's University Hospital Brno nearly three hundred visitors. Stands were prepared for them to measure blood pressure, blood sugar, learn how to properly care for their teeth and especially learn about the risk of stroke.
The event was organized for the sixth time by the Stroke Research Team of the International Clinical Research Center of St. Anne's University Hospital Brno (FNUSA-ICRC) led by her research and educational program HOBIT (Hour of Biology for Life). "The aim of the event was to raise awareness of stroke, interested people learned about prevention how to correctly recognize symptoms of stroke and especially how to respond to them in a timely and fast way," said Hana Maršálková, event organizer and manager of the HOBIT program. "There was a constant crowd at individual sites, I am glad that there was also a lot of participants on public lecture on stroke."
The awareness raising event is part of the HOBIT program. Its aim is to provide people with multimedia and simulation education with information that will enable them to save their lives to a person with a heart or brain attack.

Smlouva FNUSA-ICRC a Tor Vergata

29. 10. 2019 |

On Thursday, October 24, 2019, a cooperation agreement between the University of Rome Tor Vergata and The International Clinical Research Center of St. Anne's University Hospital Brno (FNUSA-ICRC) was ceremonially signed with the participation of the President of the South Moravian Region Bohumil Šimek and the Deputy of the Embassy of the Czech Republic in Italy.

Tor Vergata University of Rome was founded in 1982. It is a public research institution focusing on new technologies, trends and knowledge. It has more than thirty-four thousand students and is divided into six faculties. Its partners include the European Space Agency, the University of Cambridge and the Pasteur Institute in Paris. The cooperation agreement concerns in particular the School of Mathematics, Physical and Natural Sciences, specifically the Department of Chemical Sciences.

"We have a lot in common and it is about deepening existing cooperation," said FNUSA-ICRC Chair, Gorazd B. Stokin. “Joint research will take place, for example, in the development of nanomaterials for medical applications.” Both institutions cooperate, for example, in the framework of NANO-SUPREMI and PEPSA MATE grants, and in addition to intensive publishing activities, an exchange program for students is planned.

In addition to the aforementioned persons, the ceremony was also attended by FNUSA Director Vlastimil Vajdák, University Vice-Rector Tor Vergata Silvia Licoccia and other representatives of the Faculty of Science. “I also invited the management of Tor Vergata University to visit St. Anne's University Hospital Brno and FNUSA-ICRC,” added Vlastimil Vajdák.

Podpis smlouvy Tor VergataFNUSA-ICRC v Tor Vergata
utility models FNUSA-ICRC

22. 10. 2019 | 

The Industrial Property Office entered three new utility models in the utility model database, which were created in the International Clinical Research Center of St. Anne's University Hospital Brno (FNUSA-ICRC). Two of them were developed by researchers of the Interventional cardiac electrophysiology research team led by MUDr. Zdeněk Stárek, Ph.D., one of them is the team Inflammation led by Mgr. Lukáš Kubala, PhD. “This is the result of collaboration between research teams, technology transfer and patent attorneys,” emphasized Roman Polák from FNUSA-ICRC Technology Transfer Department. “These are the first three early birds, we are currently expecting more registered utility models, and working with researchers to protect patent solutions. And of course we will also actively help with their commercialization.”

The first utility model is called the "Kit for Determining the Specific Influence of Adenylate Cyclase (AC) Isoforms". There are currently a large number of available drugs, especially antihistamines or antiasthmatics, which modulate AC activity through receptors. However, more than 750 subtypes of these receptors are described and their specific modulation is very problematic. To date, only ten different AC isoforms have been identified that can be regulated differently, and research into new modulators suggests that AC can become a direct therapeutic target for next-generation drugs. To date, however, there was no commercially available technology to test for selective modulation of AC activity sensitive to the non-selective activator forskolin. These disadvantages and shortcomings are eliminated by the kit of which technical solution is the subject of the utility model.

Two other utility models entitled “High Voltage AC Source for Electroporation Purposes” and “Electroporation Generator for Ablation of Cardiac Tissues”, which was filed together with the Brno University of Technology, deal with the issue of catheter ablation of cardiac arrhythmias. Utility models are related to electroporation, this energy source is in many ways better than existing technology in terms of safety and sustained normal heart rhythm.

Two above mentioned utility models were developed in the TA ČR Gamma program: Support for verification and commercialization of research and development results at FNUSA in Brno, project number: TG02010048.

Czech certificate of Utility model – FNUSA-ICRC
Medical cannabis research conference FNUSA-ICRC

18. 10. 2019 |

MVDr. Ing. Václav Trojan, Ph.D., Head of the Clinical-Pharmacological Unit (CPU) of the International Clinical Research Center of St. Anne's University Hospital in Brno (FNUSA-ICRC), announced that the Cannabis Research Center (CRC) was established. "We decided to do this at an expert meeting where it was unanimously agreed," Trojan confirmed. “The Clinical-Pharmacological Unit (CPU) will be an integral part. Of course there will be standardized areas for the preparation of new drugs and we are also planning our own growing area for research.”

The aim of the Cannabis Research Center (CRC) should be to provide comprehensive research, ie DNA studies, in vitro studies, or testing of cannabis substances on cell cultures, animals and last but not least on volunteers and patients. "Several clinics have already shown interest in cooperation, namely cooperation in orthopedics and neurology,"  Trojan added.

In addition to the above, awareness and conference activities continue. „Together with MUDr. Radovan Hřib, head of the Center for Pain Treatment of the Anaesthesiology and Resuscitation Clinic of FNUSA, we moderated the cannabis section at the Slovak conference 21st Czech-Slovak Dialogues on Pain,” Trojan said. "Although medical cannabis is still taboo in Slovakia, a legislative change is planned next year and we should play the role of expert advisors."

In April of the next year, namely the 22nd, the sixth continuation of the professional conference Cannabis and Science is planned. “Interesting speakers are already confirmed - dr. Arno Hazekamp from the Netherlands and the Argentine expert dr. Marcelo Rubinstein, ”said Trojan. " As soon as we have the program and invitation, we will surely send it to the public!"

Novinky v oblasti výzkumu medicinálního konopí
Jan Vorisek - Biostatistics at FNUSA-ICRC

16. 10. 2019 |

REDCap (Research Electronic Data Capture) is primarily a database solution for collecting and managing research data, but it can also be used for other matters that are only marginally related to research (eg surveys). It was originally developed for the internal needs of researchers at Vanderbilt University, but is now used worldwide - especially in the academic research community. It is an international network of nearly two and a half thousand institutions in over 115 countries, with 590,000 end users. REDCap is currently used for more than 450,000 ongoing research studies.

The International Clinical Research Center of St. Anne's University Hospital Brno (FNUSA-ICRC) is also involved in this network, Jan Voříšek from the Biostatistics team is our administrator. He recently returned from the REDCapCon conference and answered some questions.

Jan, being a researcher, why use REDCap?

Because I think it's perfect for us. (smile) Seriously, most of our researchers use MS Excel or Google Sheets to record their research data. From a certain point of view, and now I run into GDPR, for example, this can be a big problem, moreover, when there is something far more sophisticated and practical – I mean REDCap. It enables creation of a database for manual data collection with bulletproof security, perfect management of access rights, takes care of data validation at the time of entry or enables cooperation on one dataset to international teams. Although it is not software for processing enormous machine-generated data, it is an ideal tool for standard research.

And what about REDCap and FNUSA-ICRC?

After a year and a half we finally have REDCap in the latest version, so it is ready to use. And it's free! It even meets the requirements of GDPR compliance… Just to give you an idea, I met a colleague from Mayo Clinic at the conference and he confirmed to me that several thousands of studies have been done at REDCap, including the most demanding clinical solutions.

So what do you plan to increase using REDCap?

Certainly I would like to create a special section on our web page with detailed information for potential users and by the end of the year I also plan to validate for the needs of clinical trials. This is still in progress, but if someone is interested in this information, it can certainly contact me, I will be happy to explain it in person.

Good luck!

Jan Voříšek - RedCap at FNUSA-ICRC - Biostatistics
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