A Joint Publication with a Nobelist Arieh Warshel
15. 2. 2019
Bioinformatics and experimental biologists from Loschmidt Laboratories and the FNUSA-ICRC Protein Engineering research team, led by Prof. Jiří Damborský and Prof. Zbyněk Prokop, worked together with a Nobel Prize laureate in Chemistry Arieh Warshel, who received the award in 2013 for the development of computer models of complex chemical systems.
Scientists have engaged in enzymatic reactions to improve their properties for practical use. Nobelist Warshel and his team dealt with theoretical calculations of enzyme variants, our scientists in Brno then experimentally created and tested the variants. Laboratory experiments were carried out by a student of molecular biology Kateřina Slánská, who was interested in the research project within the ICRC Academy. Research has shown that the chosen computational methods have great potential for the formation of new enzyme variants, which could then be used, for example, in the manufacture of drugs or the disposal of toxic substances. In January, the results of a joint scientific study published the Proceedings of the National Academy of Sciences of the United States of America (PNAS) journal.