DEMENTIA

MUDr. Kateřina SHEARDOVÁ, Ph.D.

katerina.sheardova@fnusa.cz

Katerina Sheardova is a scientific director and co-founder of the Czech Brain Aging Study (www.cbas.cz), based at the International Clinical Research Centre at St. Anne’s University Hospital in Brno. CBAS is a longitudinal, observational study on aging and dementia from two large centers in the Czech Republic combining clinical care and clinical research. She received her doctorate at Masaryk University, Brno and PhD in Neuroscience at Charles University, Prague. Dr. Sheardova is also a member of several international scientific advisory boards and pharmaceutical companies involved in the research of early diagnostics, therapy and prevention of neurodegenerative disorders.

As a neurologist, Dr. Sheardova works with patients who have a wide range of neurodegenerative disorders and memory complaints. Her primary interest is the research of early biomarkers od AD and the risk-protective factors of dementia, focusing on preventive life-style measures, yoga, mindfulness techniques and the role of glymfatic system in healthy brain aging.

Research focus

The current research of Dementia Research Group is based on the Czech Brain Aging Study (CBAS) – a unique national, multicentric, longitudinal prospective cohort study. The aim of CBAS is to study the early functional, metabolic, structural and genetic biomarkers of Alzheimer´s Disease and other dementias in blood, CSF and magnetic resonance imaging with focus on synucleinopathies, tauopathies and TDP-43-pathies. These studies are complemented by animal studies with emphasis on translational aspect of the used methodology. CBAS also explores the effect of lifestyle factors on the brain maintenance using questionnairs and nonpharmacological interventions. CBAS team consists of two core synchronized sites – Cognitive Centers at ICRC St. Anne´s University Hospital Brno and at Motol University Hospital, Prague.
Partners and collaborating institutions: University of South Florida, Tampa, FL, USA; Harvard University, Cambridge, MA, USA; Nanjing Drum Tower Hospital, Nanjing, China; EADC – European Alzheimer Disease Consortium; eDLB – European DLB consortium; Alzheon; University of Gothenburg, prof. Kaj Blennow
Offered services and expertise: Translational research, data analysis, longitudinal study, biomarkers of neurodegenerative disorders, neuropsychology, neuroimaging, cerebrospinal fluid analysis, blood biomarkers, clinical trials.

Main goals

Evaluation of neuropsychological and spatial navigation tests as an early markers of neurodegeneration.
Defining structural, metabolic and functional biomarkers on MRI and PET in humans.
Exploring epidemiological risk factors in primary and secondary prevention of dementia.

Technological equipment

3T MRI– multimodal brain imaging, diffusion tensor imaging, functional magnetic resonance imaging (fMRI).

Selected Publications:

Databáze REDCap studie CBAS s daty popisujícími změny ve struktuře a metabolismu mozku v čase u zdravých jedinců, u pacientů s mírnou kognitivní poruchou a u demencí.

Banka biologických vzorků pro budoucí genetickou a biochemickou analýzu u jedinců, kteří onemocní Alzheimerovou chorobou.

Úložiště kognitivních dat ze specifického neuropsychologického protokolu a testování poruch paměti související s poškozením hipokampu jako určité rané známky Alzheimerovy choroby.

Databáze magnetické rezonance longitudinální studie atrofie mozku u pacientů s kognitivní poruchou.

SHEARDOVA, K., VYHNÁLEK, M., NEDELSKÁ, Z., LACZÓ, J., ANDEL, R., MARCINIAK, R., CERMAN, J., LERCH, O., HORT, J. Czech Brain Aging Study (CBAS): prospective multicentre cohort study on risk and protective factors for dementia in the Czech Republic. 2019, BMJ Open, 9(12)

COUGHLAN, G., LACZÓ, J., HORT, J., MINIHANE, A.M., HORNERGER, M. Spatial navigation deficits – overlooked cognitive marker for preclinical Alzheimer disease?. Nat Rev Neurol. 2018;14(8):496-506.

NEDĚLSKÁ, Z., ANDEL, R., LACZÓ, J., VLČEK, K., HOŘÍNEK, D., LISÝ, J., SHEARDOVÁ, K., BUREŠ, J., HORT, J. Spatial navigation impairment is proportional to right hippocampal volume. Proceedings of the National Academy of Sciences of the United States of America. 2012, 109(7), 2590-2594.

LACZÓ, J., ANDEL, R., VYHNÁLEK, M., MATOŠKA, V., KAPLAN, V., NEDELSKÁ, Z., LERCH, O., GAŽOVÁ, I., MOFFAT, S., HORT, J. The effect of TOMM40 on spatial navigation in amnestic mild cognitive impairment. Neurobiology of Aging. 2015, 36(6), 2024-2033.

CHMÁTALOVÁ, Z., VYHNÁLEK, M., LACZÓ, J., HORT, J., SKOUMALOVÁ, A. Analysis of lipophilic fluorescent products in blood of Alzheimer´s disease patients. Journal of Cellular and Molecular Medicine. 2016, 20(7), 1367-1372.

Team Members:

Francesco Angelucci

prof. Rostislav Andel, Ph.D.

MUDr. Roman Bednár, Ph.D.

Jozef Dobrý

Mgr. Barbora Frantelová

Vladislava Fulínová

prof. MUDr. Jakub Hort, Ph.D.

PhDr. Daria Hudspeth

Bc. Terezie Janečková

Mgr. Zuzana Konečná

Bc. Monika Kseňáková

Mgr. Tomáš Kubík

Mgr. Monika Kunzová, Ph.D.

Ing. Monika Kurečková

prof. MUDr. Jan Laczó, Ph.D.

MUDr. Martina Mračková, Ph.D.

MUDr. Zuzana Nedelská

MUDr. Julie Nováková Martínková

Mgr. Jan Ondřej

Mgr. Daniela Světlíková

Ing. Jan Šíma

Mgr. Patrik Šimko, Ph.D.

MUDr. Rastislav Šumec, Ph.D.

Ľuboslava Švajková

Mgr. Michal Varchol

MUDr. Martin Vyhnálek

DEMENTIA

MUDr. Kateřina SHEARDOVÁ, Ph.D.

Selected Publications:

Team Members:

Assistant:

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ICRC is a joint workplace of St. Anne’s University Hospital Brno and the Faculty of Medicine, Masaryk University.