STROKE

prof. MUDr. Robert Mikulík, Ph.D.

E-mail: robert.mikulik@fnusa.cz
Tel: +420 543 184 080

What is our area of expertise?

Stroke Diagnosis and Acute Treatment. Stroke Logistics, Simulation Education, Stroke Awareness, Stroke Care Quality and Implementation Research, Pre-clinical Research, Neuroepidemiology, Clinical Trials

Team Members:

Petra Amchová, Ph.D.
Lenka Bártová
Bc. Eva Bendová
MVDr. Eliška Brhelová
Bc. Helena Bumbová, DiS.
Maranhao Neto Geraldo De Albuquerque, Ph.D.
MVDr. Jana Doležalová, Ph.D.
Mgr. Kristýna Douchová
Mgr. Kristýna Dušková
Františka Hamáková
doc. MUDr. Aleš Hejčl, Ph.D.
MVDr. Jana Hložková, Ph.D.
Mgr. Petra Hrstková
Bc. Pavel Klement
Tereza Krejčiříková
Karin Kunzová
Jana Lichá
Ing. Hana Maršálková
Mgr. Zuzana Mezerová
prof. MUDr. Robert Mikulík, Ph.D.
Mgr. Anežka Novotná
RNDr. Jaroslav Ondruš, Ph.D.
Mgr. Martin Páleník
Ing. Václav Pasáček
Mgr. Michaela Pešková
Mgr. Bc. Lucie Pražáková
MVDr. Peter Scheer, Ph.D.
Ing. Bc. Simona Skuhravá, MBA
Mgr. Slachová Martina
Ing. Steffl Ondřej
Ing. MgA. Veronika Svobodová
Ing. Pavla Šafránková, DiS.
MUDr. Ing. Mgr. Petra Šedová, Ph.D.
RNDr. Lenka Šindlerová, Ph.D.
Ing. Marie Švaňhalová, Ph.D.
Mgr. Sandra Thalerová, Ph.D.
Mgr. Helena Trubačová
prof. RNDr. Jaroslav Turánek, CSc.
Darja Urbánková
Mgr. Miroslav Vařecha, Ph.D.
Mgr. Ekaterina Volevach
doc. MUDr. Ondřej Volný, Ph.D.
Mgr. Jana Vyklická
Kristýna Znamenáčková

Assistant:

Tereza Krejčiříková
tereza.krejcirikova@fnusa.cz
+420 543 185 587

Research focus

  • Research actvites of the Stroke Research Group (STR) include development and implementation of innovative methods for the evaluation, treatment, and prevention of acute ischemic stroke. Research portfolio is designed across translational axis from basic science to clinical research and implementation research. The emphasis is on a translational approach so that knowledge gained through basic research is applied and tested in clinical practice and then translated into health care system and population
  • European Stroke Organisation, Switzerland
  • ANGELS Initative, The world-wide stroke support project, Germany
  • University of Calgary, Canada
  • Network of Stroke Centres in Central and Eastern Europe
  • Simulation training and methodology- is intended for stroke teams and professionals in stroke
  • System Engineering/Software Developing and data management
  • Preclinical Research: highly sophisticated in vitro flow models and small animal models of stroke
  • Web-based platform for education of children and lay public in stroke
  • Coordination of clinical trials

Main goals

  • Research on implementation of evidence-based treatments
  • Development of in vitro and animal model for stroke to test new diagnostics (e.g. basic thrombus imaging) and therapeutic strategies (e.g. new recanalizaton methods)
  • Identification of beter stroke awareness methods including program on stroke awareness in children

Technological equipment

  • Fully equipped Stroke Unit with neuroimaging machines
  • The Laboratory of Nanopharmacology NAPHARM is a joint workplace of the Veterinary Research Institute and FNUSA-ICR
  • IT infrastructure for medical databases and research

Selected Publications

HART, R., SHARMA, M., MUNDL, H., KASNER, S., BANGDIWALA, S., BERKOWITZ, S., SWAMINATHAN, B., LAVADOS, P., WANG, Y., WANG, Y., DAVALOS, A., SHAMALOV, N., MIKULÍK, R. et al. Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source. New England Journal of Medicine. 2018, 378(23), 2191-2201. ISSN 0028-4793. IF 70.670.

MENON, B., AL-AJLAN, F., NAJM, M., PUIG, J., CASTELLANOS, M., DOWLATSHAHI, D., CALLEJA, A., SOHN, S., AHN, S., POPPE, A., MIKULÍK, R. et al. Association of Clinical, Imaging, and Thrombus Characteristics with Recanalization of Visible Intracranial Occlusion in Patients with Acute Ischemic Stroke. JAMA. 2018, 320(10), 1017-1026. ISSN 0098-7484. IF 51.273.

ALEXANDROV, AV., KOHRMANN, M., SOINNE, L., TSIVGOULIS, G., BARRETO, AD., DEMCHUK, AM., SHARMA, VK., MIKULÍK, R. et al. Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Neurology. 2019, 18(4), 338-347. ISSN 1474-4422. IF 28.755.

Mikulík R, Eckstein J, Pearce LA, Mundl H, Rudilosso S, Olavarría VV, Shoamanesh A, Chamorro Á, Martí-Fàbregas J, Veltkamp R, Öztürk Ş, Tatlisumak T, Peacock WF, Berkowitz SD, Connolly SJ, Hart RG. Frequency and Predictors of Major Bleeding in Patients With Embolic Strokes of Undetermined Source: NAVIGATE-ESUS Trial. Stroke 2020, July; 51:2139–2147.