We educate leaders for Science and Business!

prof. Mgr. Jiří Damborský, Dr.


Key words

Alzheimer Disease, Biocatalysis, Bioinformatics, Computer Modelling, Lab-on-chip, Microfluidics, Protein Engineering, Metabolic Engineering, Mechanistic Enzymology.

Research focus

  • The research group focuses on protein and metabolic engineering for biomedicine. The group develops new theoretical concepts, software tools and lab-on-chip technologies for protein engineering. It uses these newly developed tools for the design of proteins with improved properties for biocatalysis, biodegradation, biosensing, cell culturing and differentiation. The group has published more than 200 original articles, 20 book chapters and filed 7 international patents and founded the biotechnology spin-off Enantis Ltd.
  • Bioinformatics – identification of interesting genes in genomic databases for molecular cloning and experimental characterization
  • Lab-on-Chip Technologies – development of microfluidic lab-on-chip technologies for biochemical and biomedical research
  • Pathway Engineering – design and construction of bacterial strains expressing newly assembled biochemical pathways
  • Protein Stabilization – computational design of stabilization mutations
  • International Collaborations: ETH Zurich, Switzerland; Tohoku University, Katahira, Japan; University of Cambridge, Cambridge, UK; Novo Nordisk Foundation Center for Biosustainability (CFB), Copenhagen, Denmark; Spanish National Research Council (CSIC), Madrid, Spain

Main goals

  • Computational design and engineering of hyperstable proteins
  • Application of novel theoretical concepts for proteins engineering
  • Development of user-friendly software tools and microfluidic chips

Technological equipment

  • Computer cluster
  • Circular dichroism
  • Colony picking robot
  • Hardware and software for computer modeling
  • Microfluidics
  • Pipetting robot
  • Rapid quench-flow system
  • Stopped flow-kinetic system