ACUTE CORONARY SYNDROMES

MUDr. Ota Hlinomaz, CSc.

Research focus
The Acute Coronary Syndrome Research team belongs amongst pioneers of primary percutaneous coronary intervention programs in the Czech Republic and is also one of the largest centers. The main activity of the ACS Research team is interventional cardiology, treatment of coronary artery disease by percutaneous coronary interventions and treatment of acute coronary syndromes. The main research is focused on a new stent and scaffolds development, treatment of ST-Elevation Myocardial Infarction (STEMI) patients with multivessel disease, anti-aggregation therapy after acute coronary syndromes, Tako-tsubo Cardiomyopathy, new imaging methods of coronary arteries and atherosclerotic plaque progression.

Research objectives
• Evaluate unstable coronary plaques by optical coherence tomography and near infrared spectroscopy.
• Test newly developed coronary stents and scaffolds in animal models and humans.
• Test the role of genetic polymorphisms on pharmacokinetics of antiplatelet drugs used for acute coronary syndromes treatment.

Technological equipment
• Angiography System – Digital Subtraction Angiography (DSA)
• Optical Coherence Tomography (OCT)
• Near Infrared Spectroscopy (NIRS)
• Intracoronary Ultrasound (IVUS)
• Single-Photon Emission Computed Tomography (SPECT)

Top publications

  • UTHAMARAJ, S., TEFFT, B., HLINOMAZ, O., SANDHU, G., DRAGOMIR-DAESCU, D. Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention. Jove-Journal of Visualized Experiments. 2015, SEP(103), e53100.
  • UTHAMARAJ, S., TEFFT, B., KLABUSAY, M., HLINOMAZ, O., SANDHU, G., DRAGOMIR-DAESCU, D. Design and Validation of a Novel Ferromagnetic Bare Metal Stent Capable of Capturing and Retaining Endothelial Cells. Annals of Biomedical Engineering. 2014, 42(12), 2416-2424.
  • MÁCHAL, J., PÁVKOVÁ-GOLDBERGOVÁ, M., HLINOMAZ, O., GROCH, L., VAŠKŮ, A. Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival. Medicine. 2014, 93(28), e278.
  • PLEVA, L., KUKLA, P., KUSNIEROVA, P., ZAPLETALOVA, J., HLINOMAZ, O. Comparison of the Efficacy of Paclitaxel-Eluting Balloon Catheters and Everolimus-Eluting Stents in the Treatment of Coronary In-Stent Restenosis The Treatment of In-Stent Restenosis Study. Circulation-Cardiovascular Interventions. 2016, 9(4), e003316.
  • KINCL, V., MÁCHAL, J., DROZDOVÁ, A., PANOVSKÝ, R., VAŠKŮ, A. The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. Disease Markers. 2015, 2015(2015), 232048.

Other selected results

  • Novel Ferromagnetic Bare Metal Stent Capable of Capturing and Retaining Endothelial Cells – New type of stent for Rapid healing of vascular system reducing complications associated with stent thrombosis, restenosis, and bleeding related to antiplatelet drugs.
  • Novel Ferromagnetic Stent Graft – New type ofstent graft with small diameter (3 mm) – magnetic stent graft of rapid endothelialization represents a new therapeutic approach in peripheral and coronary arteries, thereby reducing the need for prolonged anticoagulation and antiplatelet therapy.