INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY

We return the right heart beat

MUDr. Zdeněk Stárek

Research focus
The Interventional Cardiac Electrophysiology Research team is focused on clinical research of catheter navigation, 3D imaging of heart structures and image integration during catheter ablations of cardiac arrhythmias. Our main aim is prototype catheter testing and its development in animal models, based on the collaboration with researchers from Mayo Clinic, USA. The ICE team is further focused on the development of catheters for epicardial stimulation, defibrillation and ablation towards chronic experiments and new catheters with direct visualization of ablated tissue. Further areas are regenerative strategies of bradyarrhythmias, using stem cell technologies and novel ablation modalities. There is also ongoing brain vasculature research with neurologists and neurosurgeons. The magnetically navigated micro-catheter is utilized for endovascular mapping of deep brain structures in animal models, in order to help patients with epilepsy and to improve the quality of brain structures mapping. The ICE Research team is also running research on
microRNA in atrial fibrillation.

Research objectives
• Development of new catheters and devices for interventional treatment of cardiac and brain diseases.
• Clinical research of catheter navigation, 3D imaging of heart structures and image integration during catheter ablations of cardiac arrhythmias.
• Translational focus on stem cell-derived cardiomyocytes and regeneration strategies.

Main partners
• Mayo Clinic, Rochester, MN, USA
• Mount Sinai Hospital, New York, USA
• Herzzentrum Leipzig, Leipzig, Germany

Offered services and expertise
• Catheter testing both in human and in animal models.
• Technical assistance on animal studies involving imaging and electrophysiology equipment.
• Human electrophysiology clinical evaluation.
• Registry setup.

Top publications

  • Starek, Z., Lehar, F., Jez, J., Wolf, J., Kulik, T., Zbankova, A., Novak, M. Periprocedural 3D imaging of the left atrium and esophagus: comparison of different protocols of 3D rotational angiography of the left atrium and esophagus in group of 547 consecutive patients undergoing catheter ablation of the complex atrial arrhythmias. International Journal Of Cardiovascular Imaging. 2016 [Epub ahead of print].
  • NOVÁK, J., KRUŽLIAK, P., BIENERTOVÁ-VAŠKŮ, J., SLABÝ, O., NOVÁK, M. MicroRNA-206: a Promising Theranostic Marker. Theranostics. 2014, 4(2), 119-33.
  • Pesl M, Pribyl J, Acimovic I, Vilotic A, Jelinkova S, Salykin A, Lacampagne A, Dvorak P, Meli AC, Skladal P, Rotrekl V. Atomic force microscopy combined with human pluripotent stem cell derived cardiomyocytes for biomechanical sensing. Biosens Bioelectron. 2016, 28 (85), 751-757.
  • BULKOVÁ, V., FIALA, M., HAVRÁNEK, Š., ŠIMEK, J., ŠKŇOUŘIL, L., JANUŠKA, J., ŠPINAR, J., WICHTERLE, D. Improvement in Quality of Life After Catheter Ablation for Paroxysmal Versus Long-standing Persistent Atrial Fibrillation: A Prospective Study With 3-Year Follow-up. Journal of the American Heart Association. 2014, 3(4), e000881.
  • EBRILLE, E., KONEČNÝ, T., KONEČNÝ, D., SPACEK, R., JONES, P., AMBROZ, P., DESIMONE, C., POWELL, B., HAYES, D., FRIEDMAN, P., ASIRVATHAM, S. Correlation of Geomagnetic Activity With Implantable Cardioverter Defibrillator Shocks and Antitachycardia Pacing. Mayo Clinic Proceedings. 2015, 90(2), 202-208.

Other selected results

Multi-Electrode Epicardial Pacing – Systems and methods for epicardial pacing using a percutaneously delivered bifurcated pacing lead that has multiple electrodes that are directionally insulated to prevent extracardiac stimulation, including prevention of phrenic stimulation. In addition, the devices, systems, and methods can be used for ablation, defibrillation, and/or defibrillation in combination with pacing. Invention is covered by US and PCT patent application.