Improving outlooks for critically ill

MUDr. Pavel Suk, Ph.D.

  • Multicentric study assessing respiratory muscle training as a way of pre-habilitation before pulmonary resection supported by AZV has been commenced.
  • Research on acute and chronic changes of immune cells in sepsis in collaboration with the CMI team.

Research focus
The Intensive Care Research team (INC) focuses on a clinical, patient-oriented investigation of the me­chanisms of development, progression and outcomes of critical illness. The cooperation with several pre-clinical research labs provides us wide opportunities for a translational scientific approach, by combi­ning clinical with cellular and molecular data. Thanks to the cooperation with the Cellular and Molecular Immunoregulation team, the project focusing on Immunology of sepsis has been running smoothly and bringing promising results. One of our objectives is to test novel biomarkers of critical illness. Therefore, we investigate several circulating substances and monocytic surface markers in predictions of patient mortality, therapeutic response and onset of complications. Our secondary focus is peri-operative medi­cine and anestheziological management of at-risk patients.

Research objectives

  • To bring novel insights into immuno-pathophysiology of sepsis, septic shock, MODS and SIRS, which could potentially improve treatment of critically ill patients and reduce their mortality.
  • To develop novel biomarkers of critical illness, which could better stratify patients with the highest risk and identify the individuals suitable for specifically targeted therapy.
  • To bring novel findings, which could identify patients with increased peri-operative risk and develop no­vel approaches to optimize patients before, during and after surgery.

Main partners

  • Jan Frič – internal cooperation (CMI, ICRC)
  • Marcela Vlková – internal cooperation (Department of Allergology and Immunology, FNUSA)
  • Jiří Pařenica – University Hospital Brno-Bohunice, CZ
  • Y.S. Prakash – Mayo Clinic, USA

Offered services and expertise

  • Recruitment of critically ill patients, collection and analysis of clinical data.
  • Cooperation and expertise in the field of intensive care and peri-operative medicine.

Top publications

  • Hortova-Kohoutkova M, Laznickova P, Bendickova K, De Zuani M, Andrejcinova I, Tomaskova V, Suk P, Sramek V, Helan M, Fric J.: Differences in monocyte subsets are associated with short-term survival in patients with septic shock. JCMM. 2020.
  • Bartman CM, Schiliro M, Helan M, Prakash YS, Linden D, Pabelick C.: Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle. FASEB J. 2020.
  • Hortová-Kohoutková M, Tidu F, De Zuani M, Šrámek V, Helán M, Frič J.: Phagocytosis–inflammation crosstalk in sepsis: new avenues for therapeutic intervention. Shock. 2020.
  • Parenica J, Kala P, Mebazaa A, Littnerova S, Benesova K, Tomandl J, Goldbergova M, Jarkovsky J, Spinar J, Tomandlova M, Dastych M, Ince C, Lokaj P, Helanova K, Helan M, Tesak M, Legrand M.: Activation of the nitric oxide pathway is strongly associated with the risk of acute kidney injury in patients with acute myocardial infarction. Cardiorenal Medicine. 2020.
  • Lukeš M, Helán M, Šrámek V, Pavlíkova J, Staffa R, Suk P.: Impact of contralateral carotid stenosis on brain tissue oxygenation during carotid endarterectomy. Cor et Vasa. 2019.
  • HARTMAN W, HELAN M, SMELTER D, SATHISH V, THOMPSON M, PABELICK C, JOHNSON B, PRAKASH Y.: Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle. PLoS ONE. 2015.
  • HELAN M, ARAVAMUDAN B, HARTMAN W, THOMPSON M, JOHNSON B, PABELICK C, PRAKASH Y.: BDNF secretion by human pulmonary artery endothelial cells in response to hypoxia. Journal of Molecular and Cellular Cardiology. 2014.

Other selected results

  • Changes in monocyte subsets could predict the worse outcome of septic shock patients.
  • Soluble Endoglin could predict mortality in septic shock patients.
  • Nitric oxide pathway biomarkers correlate with the risk of acute kidney injury in patients with acute myocardial infarction.
  • Functions of H2S on adult and fetal airway smooth muscle.
  • Role of Brain Derived Neurotrophic Factor (BDNF) in hypoxic pulmonary artery endothelium and smooth muscle.