NONINVASIVE

CARDIAC IMAGING-NCT

doc. MUDr. Vladimír Kincl, Ph.D.

Research focus
The NCI-NCT is equipped by one of two cadmium-zinc-telluride SPECT cameras in the Czech Republic. The NCT focuses on new imaging protocols using cadmium-zinc-telluride technique in nuclear cardiology. The group successfully tested and published feasibility of low-dose myocardial perfusion protocol using 201-thallium. The research is currently focused on diagnostic and prognostic verification of this low-dose protocol. The group also plans to start imaging of myocardial sympathetic innervation using 123-iodine in patients with heart failure and performs multimodality imaging of myocardial viability in collaboration with NCI-CMR group.

Research objectives

  • Development and testing low-dose imaging protocols in nuclear cardiology.
  • Improvement of imaging protocols used for assessment and quantification of myocardial ischemia.
  • Improvement of the risk stratification in patients with heart failure.
  • Subclinical impairment of cardiac function in Duchenne dystrophy gene carriers.
  • Impairment of cardiac functions in patients with Parkinson´s disease.

Top publications

  • KAMÍNEK, M., METELKOVA, I., BUDIKOVA, M., KORANDA, P., HENZLOVA, L., HAVEL, M., SOVOVA, E., KINCL, V. Diagnosis of high-risk patients with multivessel coronary artery disease by combined cardiac gated SPET imaging and coronary calcium score. Hellenic Journal of Nuclear Medicine. 2015; 18(1), 31-34.
  • KINCL, V., MÁCHAL, J., DROZDOVÁ, A., PANOVSKÝ, R., VAŠKŮ, A. The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. Disease Markers. 2015; 2015(2015), 232048.
  • KINCL, V., FEITOVÁ, V., PANOVSKÝ, R., ŠTĚPÁNOVÁ, R. Assessment of the severity of acute pulmonary embolism using CT pulmonary angiography parameters. Biomedical papers. 2015; 159(2), 259-265.
  • KINCL, V., KAMÍNEK, M., VAŠINA, J., PANOVSKÝ, R., HAVEL, M. Feasibility of ultra low-dose thallium stress-redistribution protocol including prone imaging in obese patients using CZT camera. International Journal of Cardiovascular Imaging. 2016; 32(9), 1463-1469.
  • Bednárová V, Kincl V, Kamínek M, Vašina J, Panovský R, Máchal J. The prognostic value of ultra low-dose thallium myocardial perfusion protocol using CZT SPECT The International Journal of Cardiovascular Imaging, 35(6), 1163-1167

Other selected results

  • The NCI-NCT group has published the feasibility of ultra low-dose thallium protocol of myocardial perfusion. The administered activity was 0.5MBq per kg of body weight, which is the lowest activity described so far. The prognostic value of this protocol and comparison with magnetic resonance in cardiac volumes and ejection fraction measurement was also succesfully published.