STROKE

prof. MUDr. Robert Mikulík, Ph.D.

Research focus
Research actives of the Stroke research team (STR) include development and implementation of innova­tive methods for the evaluation, treatment, and prevention of acute ischemic stroke. Research portfolio is designed across translational axis from basic science to clinical research and implementation research. The emphasis is on a translational approach so that knowledge gained through basic research is applied and tested in clinical practice and then translated into health care system and population.

Research objectives

  • Research on implementation of evidence-based treatments.
  • Development of in vitro and animal model for stroke to test new diagnostics (e.g. basic thrombus ima­ging) and therapeutic strategies (e.g. new recanalization methods).
  • Identification of better stroke awareness methods including program on stroke awareness in children.

Main partners

  • European Stroke Organisation, Switzerland
  • ANGELS Initiative, The world-wide stroke support project, Germany
  • University of Calgary, Canada
  • Mayo Clinic, Rochester, USA

Offered services and expertise

  • Simulation training and methodology- is intended for stroke teams and professionals in stroke.
  • System Engineering/Software Developing and data management.
  • Preclinical Research: highly sophisticated in vitro flow models and small animal models of stroke.
  • Web-based platform for education of children and lay public in Stroke.
  • Coordination of clinical trials.

Top publications

  1. HART, R., SHARMA, M., MUNDL, H., KASNER, S., BANGDIWALA, S., BERKOWITZ, S., SWAMINATHAN, B., LAVADOS, P., WANG, Y., WANG, Y., DAVALOS, A., SHAMALOV, N., MIKULÍK, R. et al. Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source. New England Journal of Medicine. 2018, 378(23), 2191-2201. ISSN 0028-4793. IF 70.670.
  2. MENON, B., AL-AJLAN, F., NAJM, M., PUIG, J., CASTELLANOS, M., DOWLATSHAHI, D., CALLEJA, A., SOHN, S., AHN, S., POPPE, A., MIKULÍK, R. et al. Association of Clinical, Imaging, and Thrombus Characteristics with Recanalization of Visible Intracranial Occlusion in Patients with Acute Ischemic Stroke. JAMA. 2018, 320(10), 1017-1026. ISSN 0098-7484. IF 51.273.
  3. ALEXANDROV, AV., KOHRMANN, M., SOINNE, L., TSIVGOULIS, G., BARRETO, AD., DEMCHUK, AM., SHARMA, VK., MIKULÍK, R. et al. Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Neurology. 2019, 18(4), 338-347. ISSN 1474-4422. IF 28.755.
  4. Mikulík R, Eckstein J, Pearce LA, Mundl H, Rudilosso S, Olavarría VV, Shoamanesh A, Chamorro Á, Martí-Fàbregas J, Veltkamp R, Öztürk Ş, Tatlisumak T, Peacock WF, Berkowitz SD, Connolly SJ, Hart RG. Frequency and Predictors of Major Bleeding in Patients With Embolic Strokes of Undetermined Source: NAVIGATE-ESUS Trial. Stroke 2020, July; 51:2139–2147.

Other selected results

The Stroke Research Group has developed innovative platorms for evaluating stroke care quality data (RES-Q), as well as for providing education and testing to school children about stroke (HOBIT). Currently, an advanced medical imaging database for stroke, as well as other registry based research initatives.

Highly sophisticated in vitro 3D flow models for testing new recanalization methods.