We decipher cellular signals

Mgr. Pavel Krejčí, Ph.D.

E-mail: pavel.krejci@fnusa.cz

Key words

Morphogene Signaling, Receptor Tyrosine Kinases, Genetics of Bone Disorders, Primary Cilia, Fibroblast Growth Factor, Achondroplasia, Drug Development, Repurposing.

Research focus

  • Maintenance of tissue homeostasis depends on extracellular signals that govern basic cell functions. Receptor tyrosine kinases (RTKs) represent major molecular tools of such cell-to-cell communications. RTK importance is further emphasised by evidence of their function in disease, with more than 80 human pathologies associating with alterations in RTK genes, including cancer, developmental disorders and metabolic syndromes. Our research focuses on several poorly known areas of RTK function, such as the composition of protein complexes associating with activated RTKs at the cell membrane, nature of effectors utilized by RTKs to regulate specific cell functions, mechanisms by which RTKs interact with primary cilia and morphogene signaling, and molecular pathologies of skeletal disorders caused by RTK mutations.

Main goals

  • Unravel mechanism of primary cilia regulation by the RTKs.
  • Determine extent of transactivation among the human RTKs.
  • Develop new treatments for FGFR3-related chondrodysplasias.

Technological equipment

  • Confocal microscope, FPLC chromatography system.