doc. Mgr. Kamil Paruch, Ph.D.
Organic Synthesis, Medicinal Chemistry, Chemical Biology, Kinases, Nucleoside Analogs, Nucleases.
- The research in our laboratory focuses on development of synthetic methods and strategies for preparation of structurally non-trivial small molecules for applications in biomedical research. Specifically, our project includes:
- Development of potent inhibitors of certain „non-routine“ kinases (CLK, HIPK).
- Synthesis of new forskolin-based modulators of adenylyl cyclases
- Identification inhibitors of selected DNA repair pathways (nucleases Mre11 and Mus81).
- Preparation of new small-molecules probes of cell differentiation, and fluorescent probes for biological systems.
- Organic synthesis of small-molecule organic compounds of medium complexity.
- Medicinal chemistry – optimization of early leads.
- Total synthesis of new analogs of forskolin and testing their activity against human adenylyl cyclases.
- dentification of new inhibitors targeting underexplored protein kinases.
- SAR development around the existing proprietary inhibitors of nucleases MRE11 and Mus81; identification of sub-micromolar inhibitors.
- Synthesis and biological profiling of new carbocyclic C-nucleosides.
- HPLC with UV, MS and CAD detection
- NMR spectrometer
- microwave reactor
- high pressure reactor
- automatic purification systems