TRANSLATIONAL NEUROSCIENCE
AND AGING PROGRAM

To transport, or not to transport, that is the axon.

Gorazd Bernard Stokin, Ph.D., MD

E-mail: gorazd.stokin@fnusa.cz
Phone: +420 543 181 160

Key words

Aging, Alzheimer`s Disease, Traumatic Brain Injury, Stem Cells, Axonal Transport.

Research focus

The Lab aims to advance our understanding of aging and age-related disorders with major emphasis on Alzheimer’s disease. To this end the Lab combines basic and translational neuroscience approaches.
Among the basic neuroscience questions, the Lab focuses on deciphering the role of impairments in axonal transport and of the axonal defects in aging and neurodegeneration. Moreover, the Lab is also interested in elucidating the role of astrocytes in these processes with particular attention to the axonal biology and pathology.
Among the translational neuroscience questions, the Lab investigates cognitive, transcriptomic and proteomic changes of aging at the intersection with early clinical cognitive pheenotypes

Main goals

Identification of the earliest changes of aging and neurodegeneration
Understanding mechanism underlying aging and neurodegeneration
Generation of human stem cell derived neuronal and glial lineages to address aging and neurodegeneration

Technological equipment

Development of a novel human stem cells based traumatic injury model.
Production of antibodies for the diagnostics and therapeutics of Alzheimer´s Disease
Automated immunochemistry Scoring System

Team members

Gorazd Stokin, Ph.D. MD
Neda Dragišić, MSc.
Victorio Devoto, Ph.D.
Lucie Ernstbergerová
Monica Feole
Ing. Mária Nováková, Ph.D.
PhDr. Jan Sebastian Novotný, Ph.D.
Bc. Kateřina Texlová
Gretsen Velezmoro Jáuregui, MSc
Mgr. Jana Zelínková, Ph.D.

Selected results

Novotny J.S., Gonzalez Rivas J.P., Vassilaki M., Geda Y.E., Stokin G.B. (2022): Natural pattern of cognitive aging. Journal of Alzheimer’s disease, doi: 10.3233/JAD-220312.

Krell-Roesch J., Rakusa M., Syrjanen J.A., van Harten A.C., Lowe V.J., Jack C.R., Kremers W.K., Knopman D.S., Stokin G.B., Petersen R.C., Vassilaki M., Geda Y.E. (2022): Association between CSF biomarkers of Alzheimer’s disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging. Alzheimer’s & Dementia, 10.1002/alz.12557.

Novotny J.S., Gonzalez Rivas J.P., Medina Inojosa J.R., Lopez-Jimenez F., Geda Y.E., Stokin G.B. (2021): Investigating cognition in midlife. Alzheimer’s & Dementia: Translational Research & Clinical Investigations, 7(1): e12234.

Pink A., Krell-Roesch J., Syrjanen J.A., Vassilaki M., Lowe V.J., Vemuri P., Stokin G.B., Christianson T.J., Kremers W.K., Jack C.R., Knopman D.S., Petersen R.C., Geda Y.E. (2021): A longitudinal investigation of Ab, emotional behavior and mild cognitive impairment. Alzheimer’s & Dementia, 10.1002/alz.12504.

Foroughi M., Medina Inojosa J.R., Lopez-Jimenez F., Suarez L., Stokin G.B., Prieto M., Rocca W.A., Frye M.A., Morgan M.J. (2021): Association of bipolar disorder with major adverse cardiovascular events: A population-based historical cohort study. Psychosomatic Medicine, 10.1097/PSY.0000000000001017.

Krell-Roesch J., Syrjanen J., Vassilaki M., Lowe V.J., Vemuri P., Mielke M.M., Machulda M.M., Stokin G.B., Christianson T.J., Kremers W.K., Jack C.R., Knopman D.S., Petersen R.C., Geda Y.E. (2021): Brain regional glucose metabolism, neuropsychiatric symptoms, and the risk of incident mild cognitive impairment,: The Mayo Clinic Study of Aging. The American Journal of Geriatric Psychiatry 29(2): 179-191.

Fornetti E, Testa S., De Paolis F, Fuoco C., Bernardini S, Pozo Devoto V, Stokin G.B., Abbruzzese F., Gianittelli S.M., Mouly V., Zoccali M., Baldi J., Bearzi C., Forte G., Cannata S., Gargioli C. (2022): Dystrophic muscle affect motoneuron axon outgrowth and NMJ assembly. Advanced Materials Technologies 10.1002/202101216.

Onyango I.G., Stokin G.B. (2021): Targeting Alzheimer’s disease neuronal mitochondria as a therapeutic approach. In Clinical Bioenergetics: From Pathophysiology to Clinical Translation. Sergej M. Ostojic Ed., Elsevier. 343-364, 10.1016/B978-0-12-819621-2.00015-2.

Onyango I.G., Bennett J.P., Stokin G.B. (2021): Mitochondrially-targeted therapeutic strategies for Alzheimer’s disease. Current Alzheimer’s Research, 10.2174/1567205018666211298125855.

Onyango I.G., Jauregui G.V., Čarna M., Bennett J.P., Stokin G.B. (2021): Neuroinflammation in Alzheimer’s disease. Biomedicines. 9(5): 524.