The Kardiovize team from the International Clinical Research Centre of St. Anne’s University Hospital in Brno has prepared preventive examinations for the public, aimed at the possible detection of cardiometabolic diseases. Interested people will undergo a medical examination by a doctor, a sonograph or a nutritional counsellor.

Preventive check-ups – especially for cardiometabolic diseases – are very important. “According to the results of our Kardiovize study, approximately 60% of the adult population in Brno meets the criteria for starting lifestyle intervention programmes at an early stage of the disease. Our centre can contribute to the detection and stratification of at-risk subjects and provide effective interventions. Currently, the Kardiovize Lifestyle Centre offers screening and lifestyle interventions as part of primary prevention (i.e. before the onset of any complication). Effective interventions in the early stages of the disease prevent the development of complications and are especially designed for people who are overweight – obesity, prediabetes, hypertension, dyslipidemia, type 2 diabetes – but without the presence of complications (stroke, heart attack, etc.),” said Juan Pablo Gonzalez Rivas, head of the Kardiovize research team, adding: “Unhealthy lifestyles are the cause of most common diseases worldwide. Unhealthy diet, lack of physical activity, tobacco use and excessive alcohol consumption are the main drivers of non-communicable diseases. Lifestyle medicine offers an opportunity to prevent these diseases and complications in their early stages.”

Kardiovize is offering three packages to interested parties based on the number of tests and collections. This is a paid service. For more information, interested parties can visit the website at www.fnusa-icrc.org or contact Kardiovize experts directly at 549 185 592, 603 299 683 or email infokardiovize@fnusa.cz.

Kardiovize

The St. Anne’s University Hospital Brno has launched a trial run of its own experimental cannabis cultivation facility. It has become the first medical facility in the Czech Republic to grow medicinal cannabis. For the time being for research purposes.

St. Anne’s University Hospital Brno (FNUSA) is the leading Czech institution in the development and use of medical cannabis treatment. “We use it at our department for pain treatment. It also has indications for the treatment of many problems in other medical fields. In general, cannabis treatment raises a number of unanswered questions, yet it meets the requirements for high safety breadth. For further development of treatment and understanding of the effects, we want to follow up the clinical practice with research,” said Radovan Hřib, MD, Head of the Pain Management Centre of the Anaesthesiology and Resuscitation Clinic of FNUSA and the Faculty of Medicine MU, and added: “The cultivation facility will allow us to have our own, precisely defined material for pharmacological, preclinical or other clinical research without additional huge costs. This includes, for example, new therapeutic forms such as extraction tailored to the patient, the development of other medical varieties of medicinal cannabis, modern forms of drugs with, for example, nanoparticles, etc.”

“Our hospital was the first state medical facility in the Czech Republic to start using medical cannabis. For the first time ever, we also introduced its use in capsules, which are produced by our pharmacy. The cultivation and research is therefore the logical next step,” said the director of St. Anne’s University Hospital Brno Ing. Vlastimil Vajdák. “We hope that in the foreseeable future, with the change of legislation in the Czech Republic, we will be able to use the grown products not only for science and research, but also as medicines. The effort to link the scientific, medical and business strategies of FNUSA and FNUSA-ICRC is one of our strategic goals and the way we want to go,” added Pavel Iványi MBA, LLM, Executive Director of the International Clinical Research Centre of St. Anne’s University Hospital Brno (FNUSA-ICRC).

The combination of clinical and research at FNUSA is ideal thanks to its International Clinical Research Centre. “Connecting our own research cultivation facility to the teams at our research centre brings countless research opportunities literally under one roof. This connection and the guarantee of standardised material for our own research, in addition to the possibility of applying the results in practice, i.e. with patients, is even unique in the world,” emphasised MVDr. Václav Trojan, Ph.D., Head of the Clinical Pharmacology Unit of the International Clinical Research Centre of FNUSA.

The hospital already has a special permit to handle plants with high THC content. The cultivation plant is now in trial operation. “The cannabis grown must be of pharmaceutical quality. For example, there must be no introduction of infection from outside. Workers must observe strict hygiene measures, the possibility of pathogens being transferred from clothing or hands is a major risk. This is one of the reasons why only a very limited number of people have access to the growing areas,” explained Václav Trojan, adding that it goes without saying that no pesticides or other substances are used to promote plant growth or yield. “We have chosen a basalt wool growing system with drip irrigation control. There is also precise monitoring and control of all external factors – light, heat or humidity. We will be able to fully control and monitor the growing equipment online and remotely.”

The actual operation of the grow room is one part of the cannabis research. Scientists will investigate the effects of external conditions on the growth of the plants or the actual production of content in the inflorescence. “The extract obtained is actually a mixture of active substances from the cannabis plant. Some of them like THC have detailed effects. But what about the others? Scientists are working hard to isolate the substances and study them separately. For example, CBD cannabidiol is of great interest for its regenerative properties after exertion. Research into the preclinical part, i.e. the possibility of processing the flower for other forms of application, will also be carried out in the pharmacy areas of our clinical pharmacology unit. There are a number of methods of extracting the contents – mechanical, by organic solvents or through carbon dioxide. The extract obtained is the basis for the preparation of creams or suppositories, for example. There are many possibilities, and our research will be able to map everything thoroughly thanks to the cultivation facility,” summarises scientist Václav Trojan.

The substances extracted from cannabis, or mixtures thereof, will be tested first on cell cultures by scientists from the International Clinical Research Centre at St. Anne’s University Hospital. “The road to a clinical trial is very long for substances that are expected to become medicines. For dietary supplements, which include CBD cannabidiol, for example, it is easier. That’s why a clinical trial with CBD substances and CBD nano-forms will take place this autumn. It involves monitoring one parameter in 30 volunteers. The whole process from the preparation for the study to its completion takes a year,” added Václav Trojan. “The main goal of the whole research is the development of cannabis treatment. It has many unexplored areas and so far also many poorly scientifically based promising results. The most elaborated is the treatment of pain, but the use in neurology or dermatology also seems very promising. The question of research is definitely not a question for one “summer season” but a comprehensive development of the whole scientific discipline on the cannabis plant,” added Radovan Hřib.

Press Conference Press Conference Cannabis plant

How to improve health not only in excluded localities is solved by the project Saste Roma (Healthy Roma), which started in the International Clinical Research Center of St. Anne’s University Hospital Brno. The three-year project aims to increase health literacy about the most serious diseases and a number of experts across the Czech Republic are involved in its solution.

The average life expectancy for Romani men is 57 and for Romani women 65 years. This is approximately 18 years less compared to the majority population. Compared to the majority of the population, Roma also suffer twice as often from multiple diagnoses (more than one serious disease). It is often due to ignorance of how to take care of their health, lack of information and support for lifestyle changes or shyness from visiting a doctor. This should be changed by the Saste Roma project aimed at the prevention of serious diseases in excluded localities, the most frequent inhabitants of which are the Roma.

The result of the almost three-year project will be a number of educational tools, from information brochures, through cultural events, educational e-learning, to a mobile application. “The project will focus on the development, implementation and evaluation of a multi-year health campaign in excluded localities. We will cover the most serious diseases, whether cerebrovascular, cardiovascular, oncological or mental illnesses, “explained Hana Maršálková, head of the Saste Roma project and head of the Public Health group within the Cerebrovascular research program that implements the project. “Online tools, applications and awareness-raising events will also be available and usable for the general public, and we also dedicate a special part to schoolchildren,” added Maršálková.

An expert team is working on the outputs, which now includes about 40 experts from the ranks of doctors, sociologists, educators, health marketing specialists and experts on excluded localities. A number of institutions also took part in the project – several clinics of the St. Anne’s University Hospital Brno, the University Hospital Brno or the Masaryk Memorial Cancer Institute. An important factor of success will also be the involvement of field workers from the State Health Institute, the Regional Hygiene Station or organizations supporting Roma communities.

“Every project focused on the health of the population in socially excluded localities is very much needed and the positive effects on the health of the population are also reflected in the overall improvement of the social situation,” confirms the importance of the project MUDr. Marie Nejedlá, Head of the Public Health Support Center of the State Institute of Public Health. Dr. Nejedlá and her team of field workers will ensure the dissemination of the project’s educational tools directly in the target communities.

“The project will be complemented by a questionnaire survey in the target areas, which map the knowledge and attitudes of the population and also verify how effective the health intervention was. Thanks to the scientific approach, we want to ensure that the project and its follow-up activities will be as effective as possible, “concludes Professor Robert Mikulík, expert guarantor of the project from the St. Anne’s University Hospital Brno and guarantor of the cerebrovascular diseases section.

 

The Saste Roma project – Developing health in excluded localities is financed from the EEA Funds 2014-2021, project no. ZD-ZDOVA2-002.

The involvement of the SZÚ takes place within the project Effective support of the health of persons at risk of poverty and social exclusion OPZ ESF, reg. No. CZ.03.2.63 / 0.0 / 0.0 / 15_039 / 0009439.

Press_Conference_Saste_Roma

Thank you for your great interest, the study is already full.

Do you want to prevent the development of diabetes? Not satisfied with your weight? Are you not feeling well in your body? These three questions are part of the campaign for recruitment to a new project to support the right lifestyle, which will start during the holidays at the International Clinical Research Center of St. Anne’s University Hospital Brno (FNUSA-ICRC).

The pilot research project will be implemented by the Kardiovize research team, where scientists will focus on diseases associated with poor lifestyle. “We will first evaluate an individual’s current condition, such as physical activity, medical history, or eating habits, and use this information to determine the risk of developing type 2 diabetes,” said Juan Pablo Gonzalez Rivas, head of the research team. This will be followed by a consultation with a doctor, nutritionist and trainer in order to draw up a three-month individual plan. Its goal will be to motivate the patient to lose weight, and related improvements in glucose, lipids and blood pressure – in short, to improve his health and quality of life.

Anyone aged 25 to 75 years with a body mass index (BMI) between 25 kg / m2 and 40 kg / m2 can be included in the study. Determining the approximate BMI is simple, just a calculator. It is the ratio of weight and square root of height in meters. The pilot project will run for a total of six months, after a medical examination and examination by a nutritional therapist, the selected individuals will begin a lifestyle change program under the guidance of a specialized coach. Blood samples will also be taken during the study to measure blood fats and sugars.

“It is really a challenge for us, and if it succeeds on a local scale, we would like to expand this program for the entire Czech population. We want to help as many people as possible,” added Gonzalez Rivas.

DETAIL INFORMATION
Who we are looking for: people in the age 25–75 years, whose body mass index (BMI) value is in the range of 25 kg / m2 to 40 kg / m2 (BMI calculation: weight / square root of height in meters).

How will the project go? The project will last 6 months, during which time the selected candidates will undergo a medical examination and an examination by a nutrition therapist. After your first visit to the doctor, you should begin a lifestyle change program led by a lifestyle coach.
Meetings with the coach will take place weekly for three months and then every two weeks until the program is completed. In total it will be 16 sessions. Each session will last one hour at a time. You will receive discussion materials at each session. At home, you should record the amount of food and drink consumed, as well as the type of physical activity and its duration. Records should be kept throughout the project, ie 6 months.
During the study, blood samples will be taken to check your blood fats and sugars at baseline, after two months, and at the end of the study. If the test reveals high levels of blood pressure or blood fats, your doctor will recommend appropriate treatment in addition to lifestyle recommendations during the consultation.
Due to the current situation, which is affected by the COVID-19 pandemic, it is possible to interview the coach, both in person and online.

For whom the project is not suitable: if you suffer (or have suffered) from any of these diseases, participation in the program is unfortunately not possible for you: proven diabetes, cancer, ischemic heart disease, stroke, angina pectoris, peripheral vascular disease, heart failure or kidney disease, other serious kidney disease, osteoarthritis of the knee, ankle or hip joint, moderate to severe lung disease, or other disease that prevents moderate physical activity. Participating in the project is also not suitable for you if you are taking certain medications, such as chemotherapy, blood thinners and medicines that affect body weight (for example, orlistat, pregabalin, etc.). Another exclusion criterion is pregnancy or pregnancy planning during the project, or if you know in advance that you will not be able to attend most sessions of the program.

Project start: June 2021 (recruitment), July (start of intervention)

Please note that once the capacity is filled, recruitment to the project will be completed.

How to apply for the project?
You can apply by phone at 543 185 592, 603 299 683 (on working days, between 9.00 am and 3.00 pm) or via the email address infokardiovize@fnusa.cz.

Thank you for your great interest, the study is already full.
We will be happy to answer any questions. From all applicants, applicants meeting the project criteria will be selected and subsequently invited to participate.

We are looking forward to collaborate with you.

Prevent activation of the cellular receptor, which slows growth and causes achondroplasia. A groundbreaking method of treating genetic disorders of growth has been described by scientists from the International Clinical Research Center of St. Anne’s University Hospital Brno (FNUSA-ICRC) and Masaryk University in Brno, together with Japanese colleagues.

The key substance in this case is an RNA aptamer with the James Bond name RBM-007, which acts as a ligand trap. Ligands are usually small proteins that form complexes with cellular receptors and can activate them. In the case of achondroplasia, it is the FGFR3 receptor whose increased activity slows the growth of cartilage cells. An aptamer is an engineered portion of a ribonucleic or deoxyribonucleic acid that binds to a ligand that can no longer activate FGFR 3 receptors, thereby preventing growth disorders.

Pavel Krejčí, head of the FNUSA-ICRC Cell Signaling research team, contributed significantly to this discovery. “The Japanese company developed this RBM-007 for the treatment of AMD (Age-related Macular Degeneration), however, we noticed its potential for the treatment of growth disorders and started working in this area,” Krejčí described the beginnings of the cooperation. That was five years ago and now RBM-007 is entering the first phase of clinical trials and is being tested in Japanese patients. The results are very promising, however, testing a new drug is a long way off. “Drug for achondroplasia – Vosoritide, which I participated in the research, will reach the first patients after more than sixteen years,” Krejčí added.

The main focus of the FNUSA-ICRC Cell Signaling team, ie research into receptor tyrosine kinases, which currently includes FGFR3, is far from over. “Currently, we have about fifteen projects under development,” Krejčí confirmed. One is the study of aptamers that would not function as a ligand trap but inhibit receptors directly. The result could be a new generation of molecules with great potential for the treatment of diseases related to damage to various organs, not just bones. “We are trying to create a bridge between basic and clinical research. So far, we are doing well, hopefully it will last in the future, ” added Pavel Krejčí.

The publication was published in the prestigious journal Science Translational Medicine and can be found here:

Achondroplasia is a genetic form of dwarf growth, the height in adulthood in those affected by this disease is on average 125 cm. It is the most common form of genetic growth disorder in humans, and is caused by mutations in the FGFR3 gene. In the Czech Republic, 4-5 children with this disorder are born annually. Four years ago, scientists from the International Clinical Research Center of St. Anne’s University Hospital Brno (FNUSA-ICRC) founded register of these children, thanks to which they collect data on their health.

On Saturday, May 15, we commemorate the Day of the Fight against Stroke. St. Anne’s University Hospital Brno, together with the Sarema Rehabilitation Center, prepared a live broadcast on the topic on her Facebook page. Stroke is the second most common cause of death in the world. Every fourth person is at risk and affects patients regardless of age. There are no exceptional cases where the stroke affected the mother during childbirth, the patient with COVID-19 or the driver while driving. It is important to get to the hospital as soon as possible and start intensive rehabilitation as soon as possible after treatment.

Head of the Stroke research team of the The International Clinical Research Center of St. Anne’s University Hospital Brno and professor of neurology Robert Mikulík emphasizes that patients should not be transported to the hospital on their own axis. “If the patient travels on his own, he may arrive at the hospital without a stroke center, which provides comprehensive care for patients with cerebrovascular problems. On the contrary, when he dials 155, the rescuers themselves will contact a suitable doctor or medical facility, ”says prof. MUDr. Robert Mikulík, Ph.D., who, in addition to the research center, also works at the 1st Department of Neurology, FNUSA and LF MU.

If stroke treatment is to be effective, it must be started as soon as possible, ideally within 4.5 hours of the onset of symptoms. Time is crucial for a stroke. The sooner the patient enters the hospital, the higher his chances of recovery. Professor Mikulík also draws attention to an interesting phenomenon, namely the direct connection between COVID-19 and the occurrence of stroke. “Although it has already been shown that COVID-19 can cause stroke and the number of patients should increase, we paradoxically recorded about 15% fewer cases in the hospital during the spring of 2020,” he points out that people should not risk serious consequences and during a pandemic seek professional help.

Equally important is the early start of intensive rehabilitation, as explained by Mgr. Tereza Valíková from the Sarema Rehabilitation Center: “The sooner we start, the sooner we will address the brain and neuroplastic processes. When we start later, we often encounter patients who have already developed poor compensatory habits, which are more difficult to break down, ”he says. Thanks to the start of intensive rehabilitation in time, Mrs. Eliška, who suffered a hemorrhagic stroke during childbirth, is also slowly returning to life. “Eliška had a tumor in her head that was not known. Apparently, due to the pressure at birth, there was bleeding from the tumor and a large swelling of the brain. She fell into a coma at night. After midnight, she was taken by ambulance to the hospital and operated there urgently. The tumor was successfully removed, but the swelling of the brain managed to do great damage, “recalls Eliška’s husband, Petr. His wife is now training intensively at the Sarema Rehabilitation Center and is making great progress, which you can follow on the website www.proelisku.cz. However, due to long-term stays in therapies, she cannot see her two sons as often as she would like.
“Complete cure depends on several factors, such as the extent, age and timeliness of care. Therefore, if you suspect a stroke, contact emergency services immediately. The consequences do not have to be any or minimal, ”adds Tereza Valíková.

For more information, on Saturday 15 May at 5 pm, those interested can “tune in” to a webinar called The Story of a Stroke: The Patient’s Journey. They will learn what the first minutes of a patient look like after arriving at the hospital and how to properly rehabilitate the brain. Just join the event at this link , or the Facebook page of FNUSA-ICRC or FNUSA, who will share the broadcast.

Kardiovize research team of the International Clinical Research Center of St. Anne’s University Hospital Brno (FNUSA-ICRC) has published a new publication dealing with visceral fat. This is the first such published study in Europe.

The new Kardiovize publication deals with visceral fat, ie fat stores that are stored around vital organs. “It turned out that we can’t use the values of visceral fat defined by colleagues in the USA or Japan to determine cardiovascular risk. The local population has very different values, “said the head of the FNUSA-ICRC Kardiovize research team, dr. Juan Pablo Gonzalez Rivas. The publication was published in the professional journal Obesity Research & Clinical Practice.

A young researcher, Anna Polcrová, who studied Nutritional Therapy at the Faculty of Medicine of Masaryk University, Social Epidemiology at the Faculty of Science of Charles University and continued her studies at Masaryk University while working in the Kardiovize team. “Body fat can be stored in the human body in various areas. In principle, we distinguish between subcutaneous fat, which is located under the skin, and visceral fat, which is located inside the abdominal cavity and surrounds our organs. It is the placement of fat stores in the body that significantly affects its impact on our health. Previous research has found that fat placed under the skin is not as risky as visceral fat, because excess visceral fat is associated with metabolic abnormalities such as insulin resistance, diabetes II. type, increased risk of thrombosis or endothelial dysfunction, ie disorders of the inner lining of blood vessels. ”

And how is the level of visceral fat in the human body actually measured? A generally accepted standard method is computed tomography, which is, however, relatively expensive and exposes the patient to radioactive radiation. “We used bioelectrical impedance analysis in the patients in the study, which has the advantage of simplicity, speed and also lower costs. It is non-invasive and shows a strong correlation with the values measured by computed tomography. The bioimpedance method is based on weak electricity flowing through the body and measurements to calculate impedance (resistance), which allows to describe the composition of the human body, including areas of visceral fat. Although it may sound dangerous, this method is completely painless and can be used for people of any age. The only contraindication is the presence of a pacemaker or pregnancy, “added Anna Polcrová.

To create this analysis, the researchers used the data of 2052 participants in the long-term study Kardiovize, which is ongoing at FNUSA-ICRC. Since 2013, it has been monitoring the health of a sample of the Brno population aged 25-65, and the second wave of examinations will be completed this year. “Our results showed that the limit values of visceral fat related to cardiometabolic risk in the Czech population are different in comparison with previous studies in other populations. We observed that 90 cm2 limits in men and 109 cm2 in women were associated with the presence of cardiometabolic risk factors including high waist circumference, increased blood pressure, decreased HDL-cholesterol (so-called “good” cholesterol), elevated triglycerides and elevated glucose levels on an empty stomach. In addition, men had a higher risk of cardiometabolic complications with lower visceral fat levels compared to women. Briefly, the results showed that the distinction between high and low visceral fat and associated cardiometabolic risk must be based on population-specific cut-off values, while taking into account gender differences. The amount of adipose tissue in the body, which is assessed as the norm for women, can be considered risky for men. And it works the same way among members of different ethnicities, “added Anna Polcrová.

It should be added that a new study by the Kardiovize research team was also selected for publication in the form of an e-poster at the prestigious European Congress on Obesity. A total of 330 e-posters were received (three from FNUSA-ICRC), but only 20 of them were selected for oral presentation, two of them from FNUSA-ICRC. Among them is also the work of Anna Polcrová.

Anna_Polcrova

From 2016 to 2020 the International Clinical Research Center at St. Anne’s University Hospital Brno (FNUSA-ICRC) was financed mainly from the National Sustainability Program (the NPU II project). At the end of this period, a final evaluation took place, where members of the opponent board from the Ministry of Education, Youth and Sports together with opponents from numerous other prestigious foreign institutions evaluated the project as excellent and with an international impact. FNUSA-ICRC´s scientists thus met the goals set by the contract and achieved excellent, internationally recognized results.

Within five years, FNUSA-ICRC has received subsidies from the NPU II project with the total amount of CZK 985 million. The final report states that the Center has made significant progress towards being an internationally competitive and sustainable, multidisciplinary center of excellence in translational medicine. Both in clinical and basic research.

The final report emphasizes, inter alia, that in 2020, FNUSA-ICRC continued to develop despite the unusual and unpredictable situation associated with COVID-19. “It should be noted that we had to restrict access to laboratories, and many scientists, nurses as well as administrators devoted their time to helping patients, working in test centers or supporting other hospital services,” said Pavel Iványi, MBA, LL.M., CEO of the Center. “That is why I think we´re talking about an extraordinary result and I thank everyone who made a contribution.”

In addition to all commitments being fulfilled and results achieved, the Board of Opponents also highlighted FNUSA-ICRC´s support of mobility (supporting students and enabling them to acquire new abilities, knowledge and skills) – 943 students from all over the world took part in the project and positively acknowledged the cooperation, for example in the form of joint grants. The number of implemented clinical trials is also exceptional, mainly because FNUSA-ICRC is the only so-called Prime Site in the Czech Republic for the global IQVIA group. Just to give an idea – there are currently 170 clinical trials in progress.

Many scientific outputs of FNUSA-ICRC have been published in leading international journals and are considered key in their respective scientific fields. For example, several articles appeared in the Top 10 ranking scientific journals, an average of 17% of the total number of FNUSA-ICRC´s publications to be exact and an average of 8% appeared in the Top 5. FNUSA-ICRC researchers have published their articles in Nature, New England Journal of Medicine, Lancet Neurology, Nature Reviews Neurology, etc.

The evaluation report also contains several recommendations for the future. In particular, greater deepening of cooperation in the international field, with domestic universities, and a continued involvement of students in scientific projects. “We are aware of all these challenges and we are working on them. For example, we are negotiating with Masaryk University to deepen our cooperation,“ said director Iványi. “We are also trying to fine-tune the funding system with our founder, the Ministry of Health, so that we can ensure certainty of function for already established international scientific teams and the Center itself.”

The main goal of the NPU II project was to enable FNUSA-ICRC to develop its existing scientific potential in basic, translational and clinical research. Especially focusing on fields of cardiovascular, neuroscience and oncological research, medical biology, biomedical engineering, molecular biology and stem cells. A clear advantage is the connection to St. Anne’s University Hospital Brno, which provides direct access to a large demographic of patients. This creates optimal conditions for translational medical research, focusing on various diseases (including cardiac arrhythmias, heart failure, sleep disorders, stroke, dementia and cancer).

FNUSA-ICRC_Building    FNUSA-ICRC_Research

Feeling lonely, worried about the health of their loved ones and stress from an unstable situation. The pandemic of the COVID-19 disease affected not only the physical health of the population, but also the mental health, which has now been confirmed by research in which researchers from the International Clinical Research Center of St. Anne’s University Hospital Brno (FNUSA-ICRC) and the American Mayo Clinic.

The researchers analyzed the impact of the pandemic and related restrictive measures on mental health in the participants of the Kardiovize project, a study that has been examining the local level of health for a long time on a population sample of one percent of the city of Brno. 715 Brno residents took part in the analysis of changes in mental health during the first hard lockdown in the spring of 2020, when, in addition to services, the borders of the Czech Republic were closed. “The results showed that the incidence of increased stress and depressive symptoms increased 1.4 to 5.5times compared to the period before the COVID-19 pandemic,” said PhDr. Jan Sebastian Novotný, Ph.D., first author of an international study and member of the Translational Neuroscience and Aging Program Research group FNUSA-ICRC. “This deterioration manifested itself in all age groups and was more pronounced in women,” he added.

The study also showed that, despite a comparable deterioration in all age groups during the pandemic, younger grades suffered more mentally, which may be due to work or study insecurity, and thus financial instability. At the same time, richer life experiences and lower expectations can be expected for older age groups, which also contributes to higher mental resilience in general. The main risk factors for deteriorating mental health have been feelings of loneliness, perceptions of COVID-19 as threatening, and some negative effects on lifestyle – such as the financial effects of restrictive measures, lack of exercise or deterioration in sleep quality. On the contrary, a higher level of resilience, ie the ability to maintain a standard level of functioning despite adverse circumstances, proved to be a protective factor.

“The observed increase in the incidence of stress and depressive symptoms as well as many identified risk factors can be prevented, diagnosed and treated. It is therefore necessary to respond to these findings in a timely and targeted manner by setting up appropriate psychological and psychiatric help so as to reduce the risk of a subsequent pandemic of mental disorders in the population, “said Jan Sebastian Novotný.

The FNUSA-ICRC research team continues the study, its goal is to capture the long-term effects on the mental health of Brno residents.

Novotny

This year, the annual awareness-raising event on the occasion of World Stroke Day held by the Cerebrovascular Research Team of the International Clinical Research Center of St. Anne’s University Hospital Brno will turns into a projection on a screen. On Tuesday, October 27, immerse yourself in the world of stroke from the safety of your smartphones or computer monitors – served unpackaged by us, patients and experts. 3 panels, 12 parts, 300 minutes full of suspense, rare shots and meetings with people who will give you comprehensive information.

It will be possible to follow the entire program on the Facebook pages of the educational project HOBIT, which the research team is running. The selected videos will then also be placed on Youtube. “In cooperation with doctors, patients and other experts, we have prepared a unique program for viewers, which will acquaint them with the issue of stroke in a fun and interactive way,” said the event organizer Ing. Hana Maršálková.

Those interested can virtually walk through the premises of the FNUSA-ICRC Cerebrovascular Team, take part in an online yoga lesson or compete for original prizes. The agenda will also include a lecture on how to safely recognize a stroke, how to react to it, how to reduce its risk and not become a patient. “We will guide viewers on how to measure the values which are a risk factor for stroke at home. We also provide unique behind-the-scenes footage of a stroke patient with accompanying specialist commentary, and the online stream will be answered by a neurologist and a patient after a stroke, “added Hana Maršálková to the program of the event.

The program will be attended, for example, by prof. MUDr. Robert Mikulík, Ph.D., pioneer of modern treatment of stroke, MUDr. Ondřej Volný, Ph.D., holder of the prestigious Danubius Young Scientis Award in the field of stroke research and many other experts. The event was also financially supported by the Brno-střed district.

A stroke affects every other person. 2 million brain cells die in a minute. Take an interest. Turn on the Facebook project HOBIT on October 27 at 10 am and get vital information first hand.